Synthesis and cytotoxic activities of novel 2-(1,5-bis(aryl) penta-1,4-dien-2-yl) benzo[d]thiazol derivatives
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Novel 2-(1,5-bis(aryl) penta-1,4-dien-2-yl) benzo[d] thiazol (5a,b) and 2-(((1S,2S,E)-2(benzo[d] thiazol-2-yl)-1,5-di-arylpent-4-en-1-yl) thio) aniline (6a, b) derivatives were obtained by addition of 2aminobenzothiol to bis-benzylidinecyclobutanones (3a,b). The structures of the obtained compounds were characterized using the spectroscopic methods (NMR, IR, Elemental Analysis). Compounds 5a,b showed cytotoxic activities against C6 (Rat Brain tumor cells) and HeLa (human uterus carcinoma) in vitro. (C) 2016 ACG Publications. All rights reserved.