Browsing by Publisher "Bentham Science Publ Ltd"
Now showing items 1-20 of 21
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Acyl Thiourea Derivatives Containing Pyrazole Ring Selective Targeting of Human Aurora Kinases in Breast and Bone Cancer
(Bentham Science Publ Ltd, 2015)Several oncogenic pathways may lead to cancer. Pharmaceutical research develops efficacious compounds to inhibit these pathways. Current inhibitor drugs may block several pathways simultaneously but cause adverse and side ... -
Anticancer and Cytotoxic Activities of [Cu(C6H16N2O2)(2)][Ni(CN)(4)] and [Cu(C6H16N2O2) Pd(CN)(4)] Cyanidometallate Compounds on HT29, HeLa, C6 and Vero Cell Lines
(Bentham Science Publ Ltd, 2017)Background: In cancer, apoptosis relevant proteins-such as CaM kinase, Bcl-2 or P53, topoisomerase I, cell migration feature and DNA/BSA-macromolecules represent significant targets for current chemotherapeutics. Objective: ... -
Antioxidant activity of two wild edible mushrooms (Morchella vulgaris and Morchella esculanta) from North Turkey
(Bentham Science Publ Ltd, 2006)The ethanol extracts of Morchella vulgaris (EEMV) and Morchella esculanta (EEME) were analysed for their antioxidant activities in different systems including reducing power, free radical scavenging, superoxide anion radical ... -
Association between Vitamin K Epoxide Reductase (VKORC1)-1639G>A Polymorphism and Osteoporosis in Postmenopausal Women
(Bentham Science Publ Ltd, 2018)Introduction: Osteoporosis is a common disease, and several factors contribute to its development. Recently, there has been increasing evidence that vitamin K (VK) plays a critical role in maintaining bone strength. Vitamin ... -
Association of Cytokine Gene Polymorphisms (IL6, IL10, TNF-alpha, TGF-beta and IFN-gamma) and Graves' Disease in Turkish Population
(Bentham Science Publ Ltd, 2013)Introduction: Cytokines play a crucial role in the pathogenesis of autoimmune thyroid disease, and recent studies have demonstrated an association between cytokine gene polymorphisms and Graves' Disease (GD) in different ... -
Bioactivity-Guided Isolation of Antiproliferative Sesquiterpene Lactones from Centaurea solstitialis L. ssp solstitialis
(Bentham Science Publ Ltd, 2016)Centaurea solstitialis L. ssp. solstitialis (CSS) has been used as medicine for various diseases. In this work, root, stem and flower parts of the plant were separately extracted with methanol to execute bioassay-guided ... -
Comparison of Mean Platelet Volume, Platelet Count, Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio in the Euthyroid, Overt Hypothyroid and Subclinical Hyperthyroid Phases of Papillary Thyroid Carcinoma
(Bentham Science Publ Ltd, 2019)Introduction: Thyroid hormones are essential for the normal development, differentiation, metabolic balance and physiological function of all tissues. Mean platelet volume (MPV) indicates mean platelet size and reflects ... -
Effect of Laparoscopic Sleeve Gastrectomy on Thyroid Hormones in Euthyroid Obese Patients
(Bentham Science Publ Ltd, 2018)Introduction: In obese patients, the incidences of several thyroid disorders have increased in comparison to the general population. This study is aimed to investigate the effect of laparoscopic sleeve gastrectomy (LSG) ... -
Evaluation of Oxidative Status with Exhaled Breath 8-isoprostane Levels in Patients with Hyperthyroidism
(Bentham Science Publ Ltd, 2013)Introduction: Studies conducted so far on the effect of hyperthyroidism on oxidative stress (OS) have employed blood and urine samples. Exhaled Breath Condensate (EBC) is a non-invasive technique used to take sample from ... -
Heat Shock Protein 40-Gok1 Isolation from Toxoplasma gondii RH Strain
(Bentham Science Publ Ltd, 2013)Toxoplasma gondii is ubiquitous obligate intracellular parasite and is one of the most important pathogen for humans and animals. In humans, T. gondii has two life forms: tachyzoites and bradyzoites. Tachyzoites form of ... -
Heat Shock Protein 90 Inhibition in Cancer Drug Discovery: From Chemistry to Futural Clinical Applications
(Bentham Science Publ Ltd, 2016)Heat shock protein 90 (Hsp90) is an important member of the chaperone protein family and it is involved in stabilization, regulation, and maintenance of oncogenic client proteins with co-chaperones. Co-chaperones regulate ... -
Heat Shock Protein 90 Inhibitors in Oncology
(Bentham Science Publ Ltd, 2014)Heat shock protein 90 (Hsp90) is highly conserved chaperone protein which plays vital roles in stabilization, regulation and folding of client proteins in cancer cells. Client proteins are key macromolecules for carcinogenesis ... -
IL-1 beta and IL-1Ra Variant Profiles in Turkish Patients with Diabetic Peripheral Neuropathy
(Bentham Science Publ Ltd, 2019)Background: Diabetic peripheral neuropathy (DPN) is one of the most common complications of Type 2 diabetes mellitus (T2DM). This study was conducted to investigate the possible association between interleukin-1 beta (IL-1 ... -
A Novel Approach to Inhibit Heat Shock Response as Anticancer Strategy by Coumarine Compounds Containing Thiazole Skeleton
(Bentham Science Publ Ltd, 2015)Inhibition of the Hsp90 function is an essential therapeutic approach and several inhibitors were designed as anti-cancer agents. These inhibitors are ATPases and they aim to deregulate Hsp90 folding function. ATPase ... -
Prevalence of Nonalcoholic Fatty Liver Disease in Familial Mediterranean Fever
(Bentham Science Publ Ltd, 2020)Introduction: Nonalcoholic fatty liver disease (NAFLD) is closely associated with metabolic syndrome (MetS), insulin resistance (IR) and chronic inflammation. Although familial Mediterranean fever (FMF) patients have no ... -
Quantitative Color Doppler Ultrasonography Measurement of Thyroid Blood Flow in Patients with Graves' Disease
(Bentham Science Publ Ltd, 2020)Background: Graves' Disease is an autoimmune disorder characterized by increased levels of thyroid hormones correlated with increased thyroid blood flow. Thyroid scintigraphy is an important and conventional method. However, ... -
A SAR Study: Evaluation of Bromo Derivatives of 8-Substituted Quinolines as Novel Anticancer Agents
(Bentham Science Publ Ltd, 2017)Background: Brominated 8-hydroxy, 8-methoxy, 8-amino quinolines 5, 6, 8, 9 and novel cyano 8-hydroxyquinolines 11, 12 were evaluated in vitro for their anticancer effects on various cell lines. 5,7-Dibromo-5, 7-bromo-6, ... -
Screening of Antioxidant, Antimicrobial Activities and Chemical Contents of Edible Mushrooms Wildly Grown in the Black Sea Region of Turkey
(Bentham Science Publ Ltd, 2011)The antioxidative activities of the methanol extracts obtained from twelve commonly consumed wild edible mushrooms were investigated according to the phosphomolybdenum method, inhibition of linoleic acid peroxidation, ... -
Therapeutic Proteins: A to Z
(Bentham Science Publ Ltd, 2013)In recent years, therapeutic proteins have become an important growing class of drugs in the pharmaceutics industry. The development of recombinant DNA technology has caused to appreciation of therapeutic value of many ... -
Voltammetric Determination of Acyclovir in Human Urine Using Ultra Trace Graphite and Glassy Carbon Electrodes
(Bentham Science Publ Ltd, 2011)An electroanalytical method was developed for the direct quantitative determination of Acyclovir (Acy) in spiked human urine base on its oxidation behavior. The electrochemical oxidation and determination of Acy were easily ...
